THE UBIQUITIN-SPECIFIC PROTEASE 8 ANTAGONIZES MELATONIN-INDUCED ENDOCYTIC DEGRADATION OF MT1 RECEPTOR TO PROMOTE LUNG ADENOCARCINOMA GROWTH

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior.Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established.However, the implications of its receptors in lung adenocarcinoma have so far remained

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The Importance of Maintaining and Improving a Healthy Gut Microbiota in Athletes as a Preventive Strategy to Improve Heat Tolerance and Acclimatization

Exposure to passive heat (acclimation) and exercise under hot conditions (acclimatization), known as heat acclimation (HA), are methods that athletes include in their routines to promote faster recovery and enhance physiological adaptations and performance under hot conditions.Despite the potential positive effects of HA on health and physical perf

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Basic study on crack inspection technique using vibro-thermography

In recent study, active thermography has reached Mountaineering - Accessoires - Gants a high status as an easy and speedy defects inspection method in a NDT field.This paper newly proposes a non-disassembly and non-contact NDT method using a Vibro-Thermography for detecting and evaluating of fatigue cracks at neck parts of the conveyance roll in th

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Improving the Antigenicity of SARS-CoV-2 Vaccine Genes by Merging Mutations from Different Variants of Concern

During the COVID-19 pandemic, the early emergence of viral variants repeatedly undermined the COFFEE FILTER BASKET effects of vaccination.Our aim here is to explore strategies for improving spike vaccine gene antigenicity by merging mutations from different variants of concern (VOCs) in a single vaccine gene.To this end, newly developed recombinant

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